All About the Smooth Endoplasmic Reticulum and its Function

Posted in Uncategorized

Like it? Share it!

Smooth Endoplasmic Reticulum Function

The Endoplasmic Reticulum (ER) is an extensive system of interconnected tubules and cisternae (flattened sac-like structures) that can be found in almost all eukaryotic cells, except the red blood cells of mammals. It is basically of two types – Rough Endoplasmic Reticulum (RER) and Smooth Endoplasmic Reticulum (SER). The Endoplasmic Reticulum that does not have Ribosomes attached to its surface is known as smooth endoplasmic reticulum.

The main difference between Rough Endoplasmic Reticulum (RER) and Smooth Endoplasmic Reticulum (SER), is that RER is studded with membrane-bound ribosomes, while SER lacks this organelle. Ribosomes are concerned with protein synthesis. RER is more prominent in liver cells, as they are concerned with the production of proteins. So, cells specializing in protein synthesis have more prominent RER, while SER is prominent in those cells, which are concerned with the production of lipids.

Endoplasmic reticulum

Structure of Smooth Endoplasmic Reticulum (SER)

The ER is basically a folded structure composed of a network of interconnected disc-like sacs and tubules. All these structures (tubules and sacs) are held in their place by the cytoskeleton. The ER remains bound by a phospholipid membrane. Inside the membrane, a fluid-filled space exists, which is known as cisternal space or lumen. The lumen or cisternal space is continuous with the perinuclear space. A part of ER is also continuous with the nuclear envelope.

Structure of the Smooth & Rough Endoplasmic Reticulum(SER & RER)

The main difference in the structure of RER and SER is that RER contains ribosomes on its surface, which give it a rough appearance. SER does not contain this cell organelle, and hence the name smooth endoplasmic reticulum. SER looks like a group of smooth tubules, and is more tubular in shape than RER. Another type of endoplasmic reticulum is Sarcoplasmic Reticulum, which is a type of specialized SER that can be found in smooth, as well as striated muscles.

Functions of Smooth Endoplasmic Reticulum (SER)

SER is an important organelle found in both animal and plant cells, where it performs some specialized functions. The functions of SER can vary to an extent depending on the type of cell. More commonly, it is concerned with carrying out certain metabolic processes.

Carbohydrate and Lipid Synthesis

Smooth Endoplasmic Reticulum (SER) is mainly concerned with the synthesis of carbohydrate and lipids, and sometimes, with their metabolism. Steroid hormones are produced in SER present in the adrenal and endocrine glands. SER also produces cholesterol and membrane phospholipids, which are used for membrane formation.

Smooth Endoplasmic Reticulum (SER) is responsible for the synthesis and repair of membranes. In the liver, SER facilitates the conversion of stored glycogen to glucose. The enzyme glucose-6-phosphatase present in SER takes parts in gluconeogenesis by converting glucose-6-phosphate to glucose.

Transportation of Proteins

Though Smooth Endoplasmic Reticulum (SER) does not take part in protein synthesis unlike Rough Endoplasmic Reticulum (RER), it plays an important role in protein transportation. It regulates the transportation of proteins by acting as a transitional area for vesicles that transfer proteins to various locations. SER also transports the products of RER to Golgi apparatus and other parts of the cell.


One of the most important functions of Smooth Endoplasmic Reticulum (SER) is to detoxify the body from metabolic wastes and drugs. Drug detoxification, as well as detoxification of wastes generated in metabolic processes takes place in SER present in the liver cells. It contains enzymes that catalyze a number of reactions that can make lipid-soluble drugs and metabolic wastes water-soluble, so that they can be easily expelled from the body.

When a large amount of drugs or alcohol enter the circulatory system, the production of detoxification enzymes is increased by the liver cells. To perform the function of detoxification, Smooth Endoplasmic Reticulum (SER) doubles its surface area. Once the specific drug or toxin has been eliminated from the body, the excess SER is destroyed by a process called autophagocytosis.

Other Important Functions

The Endoplasmic Reticulum (ER), including Smooth Endoplasmic Reticulum (SER) provides surface area for the action and storage of enzymes and their products. SER attaches receptors to cell membrane proteins, and stores calcium in the muscle cells. This crucial function is carried out by the Sarcoplasmic Reticulum, which is a type of specialized SER present in the muscle cells. By releasing calcium ions, SER also regulates muscle contractions.

So, the Smooth Endoplasmic Reticulum plays a crucial role in various metabolic processes. Its existence is important for some life-sustaining processes, like protein transportation, carbohydrate and lipid synthesis, and drug detoxification.

Get Updates Right to Your Inbox

Sign up to receive the latest and greatest articles from our site automatically each week (give or take)...right to your inbox.
Blog Updates